Glycine → Lys-Gly

反応式

[NH:1](C(OC(C)(C)C)=O)[C@H:2]([C:15]([O:17]N1C(=O)CCC1=O)=O)[CH2:3][CH2:4][CH2:5][CH2:6][NH:7]C(OC(C)(C)C)=O.[NH2:32][CH2:33][C:34]([OH:36])=[O:35]>>[CH2:4]([CH2:3][C@H:2]([NH2:1])[C:15]([NH:32][CH2:33][C:34]([OH:36])=[O:35])=[O:17])[CH2:5][CH2:6][NH2:7]

参加物

反応物 2

HCID 750Glycine2 回

HCID 138755342,5-Dioxopyrrolidin-1-yl N~2~,N~6~-bis(tert-butoxycarbonyl)-L-lysinate

生成物 1

HCID 7022320Lys-Gly

実験手順

Lys-Gly-Amp was synthesized by a similar method except the amino acid starting material was Boc-Lys(Boc)-OSu and the starting drug conjugate was Gly-Amp (see Gly-Amp synthesis).

出典と根拠

ORDレコード: ord-fa47e09f15c04993b12e41a749d2bc73
出典データセット: uspto-grants-2008_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07375083B2

反応ノート

読み込み中…