(5-Chloro-2-vinylpyridin-3-yl)(2-fluoro-3-methoxy-6-vinylphenyl)methanone → 3-chloro-6-fluoro-7-methoxy-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-one
反応式
[Cl:1][C:2]1[CH:3]=[C:4]([C:10]([C:12]2[C:17]([CH:18]=[CH2:19])=[CH:16][CH:15]=[C:14]([O:20][CH3:21])[C:13]=2[F:22])=[O:11])[C:5](C=C)=[N:6][CH:7]=1>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:3]=[C:4]2[C:10](=[O:11])[C:12]3[C:13]([F:22])=[C:14]([O:20][CH3:21])[CH:15]=[CH:16][C:17]=3[CH:18]=[CH:19][C:5]2=[N:6][CH:7]=1参加物
3
実験手順
To a stirred solution of (5-chloro-2-vinylpyridin-3-yl)(2-fluoro-3-methoxy-6-vinylphenyl)methanone (6.20 g, 19.5 mmol) in toluene (1 L) was added Zhan IB catalyst (2.0 g, 2.8 mmol). The reaction mixture was purged with N2 for 20 min, heated to reflux overnight, cooled to room temperature, concentrated, and purified by flash chromatography to afford the title compound. LRMS (ESI) calc'd for (C15H9ClFNO2) [M+H]+, 290.0; found 290.0.
後処理
- customThe reaction mixture was purged with N2 for 20 min