Diethyl 2-fluoro-2-methylmalonate → N-(3,5-Difluoro-benzyl)-2-fluoro-2-methyl-malonamic acid

反応式

[F:1][C:2]1[CH:3]=[C:4]([CH:14]=[C:15]([F:17])[CH:16]=1)[CH2:5][NH:6][C:7](=[O:13])[CH:8]([CH3:12])[C:9]([OH:11])=[O:10].[F:18]C(C)(C(OCC)=O)C(OCC)=O>>[F:1][C:2]1[CH:3]=[C:4]([CH:14]=[C:15]([F:17])[CH:16]=1)[CH2:5][NH:6][C:7](=[O:13])[C:8]([F:18])([CH3:12])[C:9]([OH:11])=[O:10]

参加物

反応物 2

HCID 13061046Diethyl 2-fluoro-2-methylmalonate

HCID 21091473N-(3,5-difluoro-benzyl)-2-methyl-malonamic acid

生成物 1

HCID 69280651N-(3,5-Difluoro-benzyl)-2-fluoro-2-methyl-malonamic acid

実験手順

N-(3,5-Difluoro-benzyl)-2-fluoro-2-methyl-malonamic acid was prepared in analogy to N-(3,5-difluoro-benzyl)-2-methyl-malonamic acid (example 1) from diethyl 2-fluoro-2-methyl-malonate.

出典と根拠

ORDレコード: ord-22b0aaf6ab004299a91548b8d44a6423
出典データセット: uspto-grants-2008_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07375099B2

反応ノート

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