Dimethylamine → 11beta-[5-(Dimethylamino)pentyl]-8-vinylestra-1,3,5(10)-triene-3,17beta-diol
反応式
[CH3:1][NH:2][CH3:3].Br[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][C@H:10]1[CH2:27][C@@:25]2([CH3:26])[C@@H:21]([CH2:22][CH2:23][C@@H:24]2[OH:28])[C@@:20]2([CH:29]=[CH2:30])[C@H:11]1[C:12]1[CH:13]=[CH:14][C:15]([OH:31])=[CH:16][C:17]=1[CH2:18][CH2:19]2>>[CH3:1][N:2]([CH3:3])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][C@H:10]1[CH2:27][C@@:25]2([CH3:26])[C@@H:21]([CH2:22][CH2:23][C@@H:24]2[OH:28])[C@@:20]2([CH:29]=[CH2:30])[C@H:11]1[C:12]1[CH:13]=[CH:14][C:15]([OH:31])=[CH:16][C:17]=1[CH2:18][CH2:19]2参加物
3
実験手順
In the reaction with dimethylamine (2 M in tetrahydrofuran, 10 equivalents) analogously to instructions 17.2, 30 mg of bromide 30a yields 12 mg of amine 32a as a colorless foam (GC-MS: m/z theor.: 411, pract.: 411).
出典と根拠
- ORDレコード
- ord-72d67df3a32f457c9ae490d5888d3231
- 出典データセット
- uspto-grants-2008_05