11beta-[5-(Methylamino)pentyl]-8-vinylestra-1,3,5(10)-triene-3,17beta-diol → 11beta-{5-[Methyl(8,8,9,9,9-pentafluorononyl)amino]pentyl}-8-vinylestra-1,3,5(10)-triene-3,17beta-diol
反応式
[F:1][C:2]([F:25])([C:21]([F:24])([F:23])[F:22])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9]OS(C1C=CC(C)=CC=1)(=O)=O.[CH3:26][NH:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][C@H:33]1[CH2:50][C@@:48]2([CH3:49])[C@@H:44]([CH2:45][CH2:46][C@@H:47]2[OH:51])[C@@:43]2([CH:52]=[CH2:53])[C@H:34]1[C:35]1[CH:36]=[CH:37][C:38]([OH:54])=[CH:39][C:40]=1[CH2:41][CH2:42]2>>[CH3:26][N:27]([CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][C:2]([F:1])([F:25])[C:21]([F:22])([F:23])[F:24])[CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][C@H:33]1[CH2:50][C@@:48]2([CH3:49])[C@@H:44]([CH2:45][CH2:46][C@@H:47]2[OH:51])[C@@:43]2([CH:52]=[CH2:53])[C@H:34]1[C:35]1[CH:36]=[CH:37][C:38]([OH:54])=[CH:39][C:40]=1[CH2:41][CH2:42]2参加物
3
実験手順
In the reaction with 8,8,9,9,9-pentafluorononyltosylate analogously to instructions 22.1, 32 mg of amine 31a yields 16 mg of amine 36a as colorless crystals (GC-MS: m/z theor.: 613, pract.: 613).
出典と根拠
- ORDレコード
- ord-074ee115e7384dfe8c52ead0cedefa7c
- 出典データセット
- uspto-grants-2008_05
- 特許番号
- US07375098B2
反応ノート
読み込み中…