Methanol → Phenol, 2-(methoxymethyl)-

HRID 222343

反応式

HRID 222343 の反応式
[OH:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4][OH:5].[CH3:10]O>>[CH3:10][O:5][CH2:4][C:3]1[CH:6]=[CH:7][CH:8]=[CH:9][C:2]=1[OH:1]

参加物

3

反応物 2

HCID 887MethanolHCID 5146Salicyl Alcohol

生成物 1

HCID 182079Phenol, 2-(methoxymethyl)-収率 58%

実験手順

A solution of 2-hydroxybenzyl alcohol (5 g, 40 mmol) in methanol (25 mL) was heated in a sealed vessel at 150° C. for 4 hours. The reaction mixture was then concentrated in vacuo and the residue was purified by fractional distillation (90° C./10 mm Hg) to afford the title compound as a colourless liquid in 58% yield, 3.22 g. LRMS APCI m/z 137 [M−H]−

後処理

  1. concentrationThe reaction mixture was then concentrated in vacuo
  2. distillationthe residue was purified by fractional distillation (90° C./10 mm Hg)

出典と根拠

ORDレコード
ord-267c851da28047c39545a7f78252d4fe
出典データセット
uspto-grants-2012_06
特許番号
US08207198B2

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