Phosphorus oxychloride → (1,2-Benzoxazol-3-yl)methanesulfonyl chloride
反応式
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([CH2:10][S:11]([OH:14])(=O)=[O:12])=[N:2]1.P(Cl)(Cl)([Cl:17])=O>ClCCCl>[CH:8]1[CH:9]=[C:4]2[C:3]([CH2:10][S:11]([Cl:17])(=[O:14])=[O:12])=[N:2][O:1][C:5]2=[CH:6][CH:7]=1参加物
4
実験手順
1,2-Benzisoxazole-3-methanesulfonic acid (1) (1.00 g, 4.7 mmol) was mixed with 1,2-dichloroethane (10 mL) and phosphorous oxychloride (2.0 mL, 21 mmol). The mixture was heated to reflux until the reaction was complete, filtered through CELITE™ and evaporated to give 1,2-benzisoxazole-3-methanesulfonyl chloride (2). It was converted into zonisamide in analogy to the previous examples.
後処理
- temperatureThe mixture was heated
- temperatureto reflux until the reaction
- filtrationfiltered through CELITE™
- customevaporated
出典と根拠
- ORDレコード
- ord-d84ee85de4e3468c8ff03664d9a3af6c
- 出典データセット
- uspto-grants-2008_05
- 特許番号
- US07375233B2
反応ノート
読み込み中…