ホームMCPワークベンチSkills
ホームワークベンチ通知マイページ
llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0
  1. ホーム
  2. /反応

Potassium Carbonate → N-[1-[2-[1-[2-[3,5-Bis(hydroxymethyl)phenoxy]ethyl]cyclohexyl]ethyl]piperidin-4-yl]-N-(p-tolyl)-2-furancarboxamide

HRID 2223914
ノート
印刷プレビュー

反応式

HRID 2223914 の反応式
C([O:4][CH2:5][C:6]1[CH:7]=[C:8]([CH:41]=[C:42]([CH2:44][O:45]C(=O)C)[CH:43]=1)[O:9][CH2:10][CH2:11][C:12]1([CH2:18][CH2:19][N:20]2[CH2:25][CH2:24][CH:23]([N:26]([C:34]3[CH:39]=[CH:38][C:37]([CH3:40])=[CH:36][CH:35]=3)[C:27]([C:29]3[O:30][CH:31]=[CH:32][CH:33]=3)=[O:28])[CH2:22][CH2:21]2)[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1)(=O)C.C(=O)([O-])[O-].[K+].[K+]>CO>[OH:4][CH2:5][C:6]1[CH:7]=[C:8]([CH:41]=[C:42]([CH2:44][OH:45])[CH:43]=1)[O:9][CH2:10][CH2:11][C:12]1([CH2:18][CH2:19][N:20]2[CH2:25][CH2:24][CH:23]([N:26]([C:34]3[CH:39]=[CH:38][C:37]([CH3:40])=[CH:36][CH:35]=3)[C:27]([C:29]3[O:30][CH:31]=[CH:32][CH:33]=3)=[O:28])[CH2:22][CH2:21]2)[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1
参加物実験手順後処理出典と根拠反応ノート

参加物

4

反応物 2

HCID 11430Potassium CarbonateHCID 69144599N-[1-[2-[1-[2-[3,5-bis(acetoxymethyl)phenoxy]ethyl]cyclohexyl]ethyl]piperidin-4-yl]-N-(p-tolyl)-2-furancarboxamide

生成物 1

HCID 59715008N-[1-[2-[1-[2-[3,5-Bis(hydroxymethyl)phenoxy]ethyl]cyclohexyl]ethyl]piperidin-4-yl]-N-(p-tolyl)-2-furancarboxamide収率 94.7%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of N-[1-[2-[1-[2-[3,5-bis(acetoxymethyl)phenoxy]ethyl]cyclohexyl]ethyl]piperidin-4-yl]-N-(p-tolyl)-2-furancarboxamide (276 mg) dissolved in methanol (4 mL) was added potassium carbonate (11 mg). The solution was stirred at room temperature for 2 hours. The reaction solution was concentrated under reduced pressure. Saturated aqueous sodium bicarbonate solution was added to the solution, and it was extracted with chloroform-ethanol (80:20). The organic layer was dried over anhydrous magnesium sulfate, and filtered. The filtrate was then concentrated under reduced pressure to give the title compound (228 mg).

後処理

  1. concentrationThe reaction solution was concentrated under reduced pressure
  2. additionSaturated aqueous sodium bicarbonate solution was added to the solution, and it
  3. extractionwas extracted with chloroform-ethanol (80:20)
  4. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
  5. filtrationfiltered
  6. concentrationThe filtrate was then concentrated under reduced pressure

出典と根拠

ORDレコード
ord-58a2da11c9734fa59050ab670ba73eb3
出典データセット
uspto-grants-2008_05
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US07375115B2

反応ノート

読み込み中…

このページの内容参加物実験手順後処理出典と根拠反応ノート