3,5-Dibromo-2-(bromomethyl)pyridine → 1-(3-bromo-12H-1,11-diaza-dibenzo[a,e]cycloocten-11-yl)-ethanone

反応式

Br[C:2]1[C:3]([CH2:9]Br)=[N:4][CH:5]=[C:6]([Br:8])[CH:7]=1.[C:11]([N:14]1[C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=2[CH:19]=[CH:18]C2N=C(Cl)C(F)=CC=2C1)(=[O:13])[CH3:12]>>[Br:8][C:6]1[CH:5]=[N:4][C:3]2[CH2:9][N:14]([C:11](=[O:13])[CH3:12])[C:21]3[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=3[CH:19]=[CH:18][C:2]=2[CH:7]=1

参加物

反応物 2

HCID 534171773,5-Dibromo-2-(bromomethyl)pyridine

HCID 743934126-Acetyl-2-chloro-3-fluoro-5,6-dihydro-pyrido[3,2-c][1]benzazocine

生成物 1

HCID 692892751-(3-bromo-12H-1,11-diaza-dibenzo[a,e]cycloocten-11-yl)-ethanone収率 16%

実験手順

Compound 52C (46.6 mg, 16%) was prepared from bb (147 mg, 0.91 mmol) and 52B (300 mg, 0.91 mmol) in two steps by a route analogous to that used for the preparation of 1D.

出典と根拠

ORDレコード: ord-3d5cd47010da4519b11aba15b72e33c1
出典データセット: uspto-grants-2008_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07378426B2

反応ノート

読み込み中…