3-Amino-N-(cyclopropylmethyl)benzenesulfonamide → 7-Difluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid [3-(cyclopropylmethyl-sulfamoyl)-phenyl]-amide
反応式
[F:1][CH:2]([F:25])[C:3]1[N:8]2[N:9]=[CH:10][C:11]([C:12]([OH:14])=O)=[C:7]2[N:6]=[C:5]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][CH:16]=2)[CH:4]=1.[NH2:26][C:27]1[CH:28]=[C:29]([S:33]([NH:36][CH2:37][CH:38]2[CH2:40][CH2:39]2)(=[O:35])=[O:34])[CH:30]=[CH:31][CH:32]=1>>[CH:38]1([CH2:37][NH:36][S:33]([C:29]2[CH:28]=[C:27]([NH:26][C:12]([C:11]3[CH:10]=[N:9][N:8]4[C:3]([CH:2]([F:25])[F:1])=[CH:4][C:5]([C:15]5[CH:20]=[CH:19][C:18]([C:21]([F:23])([F:24])[F:22])=[CH:17][CH:16]=5)=[N:6][C:7]=34)=[O:14])[CH:32]=[CH:31][CH:30]=2)(=[O:35])=[O:34])[CH2:39][CH2:40]1参加物
3
反応物 2
生成物 1
実験手順
The title compound was prepared from 7-difluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (example C.1) and 3-amino-N-cyclopropylmethyl-benzenesulfonamide (example B.2) according to general procedure II. Yellow solid. MS (ISP) 564.2 [(M−H)−]; mp 238° C.