関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Ethyl 2-methylacetoacetate | HCID 701 | — |
| 反応物 | 4-Toluamidine | HCID 122754 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 5,6-dimethyl-2-(4-methylphenyl)-3H-pyrimidin-4-one | HCID 135704739 | 85.4% |
反応手順
To a solution of 4-methylbenzamidine (4.4 g) in 30 ml of ethanol was added ethyl 2-methylacetoacetate (6.1 g), and the mixture refluxed for 4 hours, giving a precipitate. The mixture was cooled to 0° C., the solid filtered off, washed with ethanol, and dried under reduced pressure, yielding 6 g of 5,6-dimethyl-2-(4-methylphenyl)-3H-pyrimidin-4-one, m.p. 250° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05428037 |
|---|
| 出典データセット | uspto-grants-1995_06 |
|---|
| ORD ID | ord-858249ef680649c6831afda0b40f7b35 |
|---|
| 出典メモ | uspto-grants-1995_06 |
|---|
