[(methoxy{[(3S,3aS,6R,6aS)-6-(nitrooxy)hexahydrofuro[3,2-b]furan-3-yl]oxy}phosphoryl)oxy]methyl 2-butyl-4-chloro-1-{[2'-(1-trityl-1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazole-5-carboxylate → HCID 178441710、化合物

反応式

C(C1N(CC2C=CC(C3C=CC=CC=3C3N(C(C4C=CC=CC=4)(C4C=CC=CC=4)C4C=CC=CC=4)N=NN=3)=CC=2)C(C(OCOP(OC)(O[C@H]2CO[C@@H]3[C@H](O[N+]([O-])=O)CO[C@H]23)=O)=O)=C(Cl)N=1)CCC.[CH2:70]([C:74]1[N:75]([CH2:92][C:93]2[CH:98]=[CH:97][C:96]([C:99]3[CH:104]=[CH:103][CH:102]=[CH:101][C:100]=3[C:105]3[N:109](C(C4C=CC=CC=4)(C4C=CC=CC=4)C4C=CC=CC=4)[N:108]=[N:107][N:106]=3)=[CH:95][CH:94]=2)[C:76]([C:80]([O:82][CH2:83][P:84]([O:89][CH2:90][CH3:91])([O:86][CH2:87][CH3:88])=[O:85])=[O:81])=[C:77]([Cl:79])[N:78]=1)[CH2:71][CH2:72][CH3:73]>>[CH2:70]([C:74]1[N:75]([CH2:92][C:93]2[CH:98]=[CH:97][C:96]([C:99]3[CH:104]=[CH:103][CH:102]=[CH:101][C:100]=3[C:105]3[NH:109][N:108]=[N:107][N:106]=3)=[CH:95][CH:94]=2)[C:76]([C:80]([O:82][CH2:83][P:84]([O:89][CH2:90][CH3:91])([O:86][CH2:87][CH3:88])=[O:85])=[O:81])=[C:77]([Cl:79])[N:78]=1)[CH2:71][CH2:72][CH3:73]

参加物

反応物 2

HCID 86652101[(methoxy{[(3S,3aS,6R,6aS)-6-(nitrooxy)hexahydrofuro[3,2-b]furan-3-yl]oxy}phosphoryl)oxy]methyl 2-butyl-4-chloro-1-{[2'-(1-trityl-1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazole-5-carboxylate

HCID 86652102(diethoxyphosphoryl)methyl 2-butyl-4-chloro-1-{[2'-(1-trityl-1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazole-5-carboxylate

生成物 1

HCID 178441710HCID 178441710、化合物

実験手順

The title compound was prepared by following step E in Example 13, except that the reagent [(methoxy{[(3S,3aS,6R,6aS)-6-(nitrooxy)hexahydrofuro[3,2-b]furan-3-yl]oxy}phosphoryl)oxy]methyl 2-butyl-4-chloro-1-{[2′-(1-trityl-1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazole-5-carboxylate was replaced by (diethoxyphosphoryl)methyl 2-butyl-4-chloro-1-{[2′-(1-trityl-1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazole-5-carboxylate. 1H NMR (500 MHz, CDCl3) δ 8.00 (dd, J=7.7, 1.3 Hz, 1H), 7.57 (t, J=7.4 Hz, 1H), 7.50 (td, J=7.6, 1.4 Hz, 1H), 7.44 (d, J=7.8 Hz, 1H), 7.12 (d, J=8.2 Hz, 2H), 6.87 (d, J=8.0 Hz, 2H), 5.45 (s, 2H), 4.48 (d, J=8.9 Hz, 2H), 4.11 (quintet, J=7.3 Hz, 4H), 2.71 (t, J=7.8 Hz, 2H), 1.73 (quintet, J=7.7 Hz, 2H), 1.39 (sextet, J=7.4 Hz, 2H), 1.30 (t, J=7.1 Hz, 6H), 0.90 (t, J=7.5 Hz, 3H); LC-MS: m/z 587.1 (M+H).

出典と根拠

ORDレコード: ord-aa8b93181a1d4552b485fb8d5a792d02
出典データセット: uspto-grants-2012_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08207208B2

反応ノート

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