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Triethylamine → HCID 178483833、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Diethyl chlorophosphate | HCID 13139 | — |
| 反応物 | 3-(3,4-Difluorophenyl)prop-2-enoic acid | HCID 145486 | — |
| 反応物 | HCID 178483797 | HCID 178483797 | — |
| 触媒 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | HCID 178483833 | HCID 178483833 | — |
反応手順
Using 1.1 g of 3,4-difluorocinnamic acid, 1.4 ml of diethyl chlorophosphate, 1.4 ml of triethylamine, 60 ml of methylene chloride, 1.4 ml of N-(2-dimethylaminoethyl)-trans-4-methylcyclohexylamine (Example 78), and 0.25 g of 4-dimethylaminopyridine, a reaction similar to that conducted in Example 81 was carried out. As a result, 1.74 g of N-(2-dimethylaminoethyl)-N-(trans-4-methylcyclohexyl)-3,4-difluorocinnamamide (a compound of the present invention) was obtained as white crystal, which had the following physiochemical properties:
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05344845 |
| 出典データセット | uspto-grants-1994_09 |
| ORD ID | ord-113951c4b7374704bebb44fd9c4485fb |
| 出典メモ | uspto-grants-1994_09 |