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Diethyl chlorophosphate → HCID 178475398、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diethyl chlorophosphate | HCID 13139 | — |
| 反応物 | 3,4-Diacetoxycinnamic acid | HCID 99103 | — |
| 反応物 | Caffeic Acid | HCID 689043 | — |
| 反応物 | HCID 178483797 | HCID 178483797 | — |
| 触媒 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 溶媒 | Triethylamine | HCID 8471 | — |
| 生成物 | HCID 178475398 | HCID 178475398 | — |
反応手順
Using 3.4 g of 3,4-diacetoxycinnamic acid derived from caffeic acid by the acetylation thereof, 2.8 ml of diethyl chlorophosphate, 2.7 ml of triethylamine, 100 ml of methylene chloride, 3.0 ml of N-(2-dimethylaminoethyl)-trans-4-methylcyclohexylamine (Example 78), and 0.5 g of 4-dimethylaminopyridine, a reaction similar to that conducted in Example 81 was carried out. As a result, 0.68 g of N-(2-dimethylaminoethyl)-N-(trans-4-methylcyclohexyl)-3,4-diacetoxycinnamamide (a compound of the present invention) was obtained as pale yellow crystal, which had the following physiochemical properties:
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05344845 |
| 出典データセット | uspto-grants-1994_09 |
| ORD ID | ord-2991a9b4149447f3a582a4b3de1d9c97 |
| 出典メモ | uspto-grants-1994_09 |