化工社化工社 化学情報印刷レポート · 研究参考用
Triethylamine → HCID 178490509、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Diethyl chlorophosphate | HCID 13139 | — |
| 反応物 | 4-Acetoxy-3-methoxy-cinnamic acid | HCID 75775 | — |
| 反応物 | HCID 178483796 | HCID 178483796 | — |
| 触媒 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | HCID 178490509 | HCID 178490509 | — |
反応手順
Using 2.5 g of 4-acetoxy-3-methoxycinnamic acid, 2.8 ml of diethyl chlorophosphate, 2.7 ml of triethylamine, 100 ml of methylene chloride, 3 ml of N-(2-dimethylaminoethyl)-cis-4-methylcyclohexylamine (Example 110), and 0.5 g of 4-dimethylaminopyridine, a reaction similar to that conducted in Example 75 was carried out. As a result, 1.6 g of N-(2-dimethylaminoethyl)-N-(cis-4-methylcyclohexyl)-4-hydroxy-3-methoxycinnamamide (a compound of the present invention) was obtained as white crystal, which had the following physiochemical properties:
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05344845 |
| 出典データセット | uspto-grants-1994_09 |
| ORD ID | ord-2e446c2251a04c37ac4935119a930ff8 |
| 出典メモ | uspto-grants-1994_09 |