Potassium Hydroxide → HCID 178490520、化合物

HRID 2225597ノート

反応式

HRID 2225597 の反応式
[CH3:1][C@H:2]1[CH2:7][CH2:6][C@H:5]([NH:8][C:9](=[O:31])[CH:10]=[CH:11][C:12]2[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][C:24]([O:26]CC)=[O:25])=[C:14]([O:29][CH3:30])[CH:13]=2)[CH2:4][CH2:3]1.[OH-].[K+]>CO>[CH3:1][C@H:2]1[CH2:7][CH2:6][C@H:5]([NH:8][C:9](=[O:31])[CH:10]=[CH:11][C:12]2[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][C:24]([OH:26])=[O:25])=[C:14]([O:29][CH3:30])[CH:13]=2)[CH2:4][CH2:3]1

参加物

4

反応物 2

HCID 14797Potassium HydroxideHCID 178471447HCID 178471447、化合物

生成物 1

HCID 178490520HCID 178490520、化合物収率 93.3%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Using 2.5 g of N-(trans-4-methylcyclohexyl)-4-[5-(ethyoxycarbonyl) pentyloxy]-3-methoxycinnamamide (Example 177), 20 ml of 2 M aqueous potassium hydroxide solution, and 80 ml of methanol, a reaction similar to that conducted in Example 169 was carried out. As a result, 2.18 g of N-(trans-4-methylcyclohexyl)-4-(5-carboxypentyloxy)-3-methoxycinnamamide (a compound of the present invention) was obtained as white crystal, which had the following physiochemical properties:

後処理

  1. customa reaction similar to

出典と根拠

ORDレコード
ord-5f0c3fc7b5b84d5096a740cd012faaae
出典データセット
uspto-grants-1994_09
特許番号
US05344845

反応ノート

読み込み中…