Potassium Hydroxide → 2-(p-Fluorophenyl)-6-isopropylphenol

HRID 2225796ノート

反応式

HRID 2225796 の反応式
C([O:3][C:4]1[C:5]([C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)=[CH:6][CH:7]=[CH:8][C:9]=1[CH:10]([CH3:12])[CH3:11])=O.[OH-].[K+]>C(O)C>[F:19][C:16]1[CH:15]=[CH:14][C:13]([C:5]2[C:4]([OH:3])=[C:9]([CH:10]([CH3:11])[CH3:12])[CH:8]=[CH:7][CH:6]=2)=[CH:18][CH:17]=1

参加物

4

反応物 2

HCID 14797Potassium HydroxideHCID 190043884'-Fluoro-3-(1-methylethyl)[1,1'-biphenyl]-2-ol formate

生成物 1

HCID 146639662-(p-Fluorophenyl)-6-isopropylphenol収率 106.6%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒2 回

実験手順

To a solution of 4'-fluoro-3-(1-methylethyl)[1,1'-biphenyl]-2-ol formate (2 g) in ethanol (5 mL) was added a 10% solution of potassium hydroxide in ethanol (10 mL) and the reaction mixture was stirred at room temperature for 1 hour. The reaction was concentrated in vacuo, and the residue was partitioned between dichloromethane (20 mL) and 1N hydrochloric acid (20 mL). The separated aqueous layer was extracted with dichloromethane (2×20 mL), then the combined organic layers were washed with water, dried (MgSO4) and evaporated to furnish 1.9 g of 4'-fluoro-3-(1-methylethyl) [1,1'-biphenyl]-2-ol as a oil which solidified on standing. A small sample was sublimed to give the analytical specimen, mp 41°-43° C.

後処理

  1. concentrationThe reaction was concentrated in vacuo
  2. customthe residue was partitioned between dichloromethane (20 mL) and 1N hydrochloric acid (20 mL)
  3. extractionThe separated aqueous layer was extracted with dichloromethane (2×20 mL)
  4. washthe combined organic layers were washed with water
  5. dry with materialdried (MgSO4)
  6. customevaporated

出典と根拠

ORDレコード
ord-b3e9641edba9470eaa510319c6aa4b2b
出典データセット
uspto-grants-1994_09
特許番号
US05344843

反応ノート

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