Water → HCID 19004319、化合物

HRID 2225815ノート

反応式

HRID 2225815 の反応式
[Br:1][CH2:2][C:3](Cl)=[O:4].[F:6][C:7]([F:23])([F:22])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[CH2:14][CH2:15][N:16]1[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1.O>ClCCl>[Br:1][CH2:2][C:3]([N:19]1[CH2:18][CH2:17][N:16]([CH2:15][CH2:14][C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[C:7]([F:22])([F:23])[F:6])[CH2:21][CH2:20]1)=[O:4]

参加物

5

反応物 3

HCID 962WaterHCID 89602Bromoacetyl chlorideHCID 30233251-[2-(trifluoromethyl)phenethyl]piperazine

生成物 1

HCID 19004319HCID 19004319、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Bromoacetyl chloride (0.125 mL) was added slowly to a chilled (5 ° C.) solution of 1-[2-[2-(trifluoromethyl)phenyl]ethyl]piperazine (0.774 g) in dichloromethane (20 mL) and the mixture was stirred in an ice bath for 45 minutes, then at room temperature for 18 hours. After the addition of water (20 mL), the organic layer was separated and washed in turn with 0.5N hydrochloric acid and sodium bicarbonate solution. The dried (MgSO4) extract was evaporated to give 0.5 g of 1-(2-bromo-1-oxoethyl)-4-[2-[2-(trifluoromethyl)phenyl]ethyl]piperazine.

後処理

  1. waitat room temperature for 18 hours
  2. customthe organic layer was separated
  3. washwashed in turn with 0.5N hydrochloric acid and sodium bicarbonate solution
  4. dry with materialThe dried (MgSO4)
  5. extractionextract
  6. customwas evaporated

出典と根拠

ORDレコード
ord-e122b200a7934759ba9a1ebb41fb5c15
出典データセット
uspto-grants-1994_09
特許番号
US05344843

反応ノート

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