Phosgene → N-(3,5-Dimethylphenyl)-N-phenylcarbamoyl chloride

HRID 2226035ノート

反応式

HRID 2226035 の反応式
[CH3:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:5]=[C:6]([CH3:8])[CH:7]=1.[C:16](Cl)([Cl:18])=[O:17]>C1(C)C=CC=CC=1>[CH3:1][C:2]1[CH:3]=[C:4]([N:9]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[C:16]([Cl:18])=[O:17])[CH:5]=[C:6]([CH3:8])[CH:7]=1

参加物

4

反応物 2

HCID 6371PhosgeneHCID 127551993,5-Dimethyl-N-phenylaniline

生成物 1

HCID 18965188N-(3,5-Dimethylphenyl)-N-phenylcarbamoyl chloride収率 99%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒2 回

実験手順

A solution of 5.5 g (27.9 mmole) of N-(3,5-dimethylphenyl)aniline, 27.9 mL of 1.93M phosgene in toluene and 15 mL of toluene was heated at 90° C. under nitrogen for 2 hours with stirring. The solution was cooled, flushed with nitrogen for 2 hours to remove excess phosgene and concentrated in vacuo to give 7.15 g (99%) of a red oil.

後処理

  1. temperatureThe solution was cooled
  2. customflushed with nitrogen for 2 hours
  3. customto remove excess phosgene
  4. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-c46cf70c2f554b9a9763425014c73ee9
出典データセット
uspto-grants-1994_09
特許番号
US05344830

反応ノート

読み込み中…