関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Methyl chloroformate | HCID 6586 | — |
| 反応物 | 2-Amino-4,5,6,7-tetrahydro-1,3-benzothiazol-7-one | HCID 587850 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | Methyl (7-oxo-4,5,6,7-tetrahydrobenzothiazol-2-yl)carbamate | HCID 59703189 | — |
反応手順
572 μl of methyl chloroformate (7.3 mmol) are added to a solution of 500 mg of 2-amino-5,6-dihydro-4H-benzothiazol-7-one (2.4 mmol) in 5 ml of pyridine. The reaction mixture is stirred at 50° C. for 15 h and then diluted with ethyl acetate; the mixture is then extracted by shaking, in each case 2×, with water and cold 1 N hydrochloric acid. The organic phase is dried and evaporated. Yield: 290 mg
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08207349B2 |
|---|
| 出典データセット | uspto-grants-2012_06 |
|---|
| ORD ID | ord-c55ba04fda9c408b8eb124b51a903ab9 |
|---|
| 出典メモ | uspto-grants-2012_06 |
|---|
