Potassium Hydroxide → HCID 54288038、化合物

HRID 2226176ノート

反応式

HRID 2226176 の反応式
[CH3:1][C:2]1([CH3:20])[CH2:11][C:10]([CH3:13])([CH3:12])[C:9]2[C:4](=[CH:5][C:6]([C:14]#[C:15][Si](C)(C)C)=[CH:7][CH:8]=2)[O:3]1.[OH-].[K+]>C(O)(C)C>[CH3:1][C:2]1([CH3:20])[CH2:11][C:10]([CH3:12])([CH3:13])[C:9]2[C:4](=[CH:5][C:6]([C:14]#[CH:15])=[CH:7][CH:8]=2)[O:3]1

参加物

4

反応物 2

HCID 14797Potassium HydroxideHCID 189663522,2,4,4-Tetramethyl-7-trimethylsilylethynyl-chroman2 回

生成物 1

HCID 54288038HCID 54288038、化合物

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

実験手順

To a solution of 1.16 g (4.1 mmol) of 2,2,4,4-tetramethyl-7-trimethylsilylethynyl-chroman (Compound 43) in 3 ml of isopropanol was added 5 ml of ethanolic KOH solution. The reaction mixture was stirred at room temperature for 24 hours and the alcohol was then removed under vacuum. The residue was extracted with 2×10 ml of ether and the combined ether extracts were washed with 15 ml of water and 20 ml of saturated NaCl solution and then dried (MgSO4). The solvent was removed in vacuo and the residue purified by Kugelrohr distillation to give the title compound as a white crystalline solid.

後処理

  1. customthe alcohol was then removed under vacuum
  2. extractionThe residue was extracted with 2×10 ml of ether
  3. washthe combined ether extracts were washed with 15 ml of water and 20 ml of saturated NaCl solution
  4. dry with materialdried (MgSO4)
  5. customThe solvent was removed in vacuo
  6. distillationthe residue purified by Kugelrohr distillation

出典と根拠

ORDレコード
ord-d93039f70b704a81b647a62bc6729938
出典データセット
uspto-grants-1994_09
特許番号
US05346915

反応ノート

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