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Sodium cyanoborohydride → N,N-diethyl-5-phenyl-3,5-dihydroxypentanamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium cyanoborohydride | HCID 5003444 | — |
| 反応物 | N,N-diethyl-5-phenyl-5-hydroxy-3-oxopentanamide | HCID 18967271 | — |
| 触媒 | Chlorotitanium triisopropoxide | HCID 3084342 | — |
| 生成物 | N,N-diethyl-5-phenyl-3,5-dihydroxypentanamide | HCID 19003821 | 70.2% |
反応手順
By carrying out the reaction as in Example 9 but starting from 1.02 g of N,N-diethyl-5-phenyl-5-hydroxy-3-oxopentanamide (3.92 mmol), 1.05 cm3 of titanium chloride triisopropoxide (4.18 mmol) and from 283.9 mg of sodium cyanoborohydride (4.28 mmol), there is obtained, with a yield of 70.2%, 730 mg of N,N-diethyl-5-phenyl-3,5-dihydroxypentanamide for which the syn/anti ratio is equal to 80/20.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05347039 |
| 出典データセット | uspto-grants-1994_09 |
| ORD ID | ord-a279125cc388433fadb42102b4837784 |
| 出典メモ | uspto-grants-1994_09 |