関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Piperidine, 1-(2-chloroethyl)-, hydrochloride | HCID 74826 | — |
| 反応物 | Bis(2-amino-1H-imidazole) sulphate | HCID 135136 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 1-(2-(Piperidin-1-YL)ethyl)-1H-imidazol-2-amine | HCID 53402474 | 22.6% |
反応手順
2-Aminoimidazole monosulfate (500 mg, 1.89 mmol) and potassium carbonate (580 mg, 4.16 mmol) were suspended in DMF (2 mL) and chloroethyl piperidine mono hydrochloride (766 mg, 4.16 mmol) was added. The reaction was heated at 100° C. for 2.5 hours before being cooled to room temperature and filtered. The filtrate was concentrated and purified by column chromatography (95:4.5:0.5 dichloromethane:methanol:aqueous ammonia) and the product was isolated as a brown oil (83 mg, 11%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08207334B2 |
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| 出典データセット | uspto-grants-2012_06 |
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| ORD ID | ord-5a74d01fdcd14d459f877a5ccbc1b94d |
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| 出典メモ | uspto-grants-2012_06 |
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