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1,2-Ethanedithiol → 7-benzyloxycarbonyl-1,4-dithia-7-azaspiro [4.4]nonane-8(S)carboxylic acid, ethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,2-Ethanedithiol | HCID 10902 | — |
| 反応物 | Ethyl (S)-1-Cbz-4-oxopyrrolidine-2-carboxylate | HCID 14540986 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 7-benzyloxycarbonyl-1,4-dithia-7-azaspiro [4.4]nonane-8(S)carboxylic acid, ethyl ester | HCID 14540988 | — |
反応手順
As described in Example 23, react 1-benzyloxycarbonyl-4-keto-(S)-proline, ethyl ester (prepared from the acid by esterification in ethanol) with 1,2-ethanedithiol to obtain 7-benzyloxycarbonyl-1,4-dithia-7-azaspiro [4.4]nonane-8(S)carboxylic acid, ethyl ester, a yellow oil [α]D26 -21.0° (ethanol).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05348944 |
| 出典データセット | uspto-grants-1994_09 |
| ORD ID | ord-ab38eb5af0614fbfb34d4b88e74bb901 |
| 出典メモ | uspto-grants-1994_09 |