Sodium Cyanide → 5-Bromopyrimidine-2-carbonitrile

HRID 222653

反応式

HRID 222653 の反応式
[C-:1]#[N:2].[Na+].[Br:4][C:5]1[CH:6]=[N:7][C:8](Cl)=[N:9][CH:10]=1>CN(C)C=O.O>[Br:4][C:5]1[CH:6]=[N:7][C:8]([C:1]#[N:2])=[N:9][CH:10]=1

参加物

5

反応物 2

HCID 8929Sodium CyanideHCID 6066655-Bromo-2-chloropyrimidine

生成物 1

HCID 6865465-Bromopyrimidine-2-carbonitrile

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6228Dimethylformamide溶媒

実験手順

Sodium cyanide (2.30 g, 46.6 mmol) was dissolved in dimethylformamide (60 ml) and treated with 5-bromo-2-chloropyrimidine (6.0 g, 31.1 mmol). The resulting mixture was stirred at room temperature for 18 hours, diluted with water and extracted with dichloromethane. The dichloromethane extracts were combined, washed with water, dried (magnesium sulphate), filtered and concentrated in vacuo. The crude product was purified by column chromatography eluting with a mixture of ethyl acetate:hexane (1:4) to afford the title compound (D38).

後処理

  1. extractionextracted with dichloromethane
  2. washwashed with water
  3. dry with materialdried (magnesium sulphate)
  4. filtrationfiltered
  5. concentrationconcentrated in vacuo
  6. customThe crude product was purified by column chromatography
  7. washeluting with a mixture of ethyl acetate:hexane (1:4)

出典と根拠

ORDレコード
ord-a84687f9b7854a1796316c632dea7ae1
出典データセット
uspto-grants-2012_06
特許番号
US08207331B2

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