Bromopinacolone → SBB058976

HRID 2226817ノート

反応式

HRID 2226817 の反応式
Br[CH2:2][C:3](=[O:8])[C:4]([CH3:7])([CH3:6])[CH3:5].[C:9]1([CH3:18])[CH:14]=[CH:13][C:12]([S:15]([O-:17])=[O:16])=[CH:11][CH:10]=1.[Na+]>CS(C)=O>[C:9]1([CH3:18])[CH:14]=[CH:13][C:12]([S:15]([CH2:2][C:3](=[O:8])[C:4]([CH3:7])([CH3:6])[CH3:5])(=[O:17])=[O:16])=[CH:11][CH:10]=1

参加物

4

反応物 2

HCID 21642BromopinacoloneHCID 2723791Sodium p-toluenesulfinate

生成物 1

HCID 264831SBB058976収率 86.1%

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒

実験手順

To a solution of 1-bromo-3,3-dimethylbutan-2-one (33.3 g, 0.19 mole) in dimethylsulfoxide (330 ml), sodium p-toluenesulfinate (34.9 g, 0.20 mole) was added in a small portion at 30°-40° C., and stirring was continued at 60°-70° C. for 18 hours. The resultant mixture was poured into ice-cold H2O (2 l), the precipitate was filtered by suction, washed with H2O and dried to give 41.6 g of 1-(p-toluenesulfonyl)-3,3-dimethylbutan-2-one as white crystals.

後処理

  1. filtrationthe precipitate was filtered by suction
  2. washwashed with H2O
  3. customdried

出典と根拠

ORDレコード
ord-2444b0984a314c35bf66e35b76e5ea89
出典データセット
uspto-grants-1994_09
特許番号
US05350660

反応ノート

読み込み中…