Lithium amide → 3-Dimethylamino-5-(methylthio)benzo[b]thiophene-2-carboxamide
反応式
[CH3:1][N:2]([CH3:18])[C:3]1[C:4]2[CH:15]=[C:14]([S:16][CH3:17])[CH:13]=[CH:12][C:5]=2[S:6][C:7]=1[C:8](OC)=[O:9].[NH2-:19].[Li+]>>[CH3:1][N:2]([CH3:18])[C:3]1[C:4]2[CH:15]=[C:14]([S:16][CH3:17])[CH:13]=[CH:12][C:5]=2[S:6][C:7]=1[C:8]([NH2:19])=[O:9]参加物
3
実験手順
Prepared from methyl 3-dimethylamino-5-(methylthio)benzo[b]thiophene-2-carboxylate by reaction with lithium amide as described in Example 19. Purification of the crude product by flash chromatography (silica gel, elution with 30% ethyl acetate in hexane) gives 64% of product; mp=140°-142° C.
後処理
- customPurification of the crude product
- washby flash chromatography (silica gel, elution with 30% ethyl acetate in hexane)
出典と根拠
- ORDレコード
- ord-7857070c950747879c9bcfc79a032e5e
- 出典データセット
- uspto-grants-1994_09
- 特許番号
- US05350748
反応ノート
読み込み中…