Benzenepropanoic acid, 4-hydroxy-, methyl ester → Methyl 3-[4-[1-(4-pyridyl)piperidin-4-yl]methoxyphenyl]propionate

HRID 2227

反応式

HRID 2227 の反応式
[OH:1][CH2:2][CH:3]1[CH2:8][CH2:7][N:6]([C:9]2[CH:14]=[CH:13][N:12]=[CH:11][CH:10]=2)[CH2:5][CH2:4]1.O[C:16]1[CH:21]=[CH:20][C:19]([CH2:22][CH2:23][C:24]([O:26][CH3:27])=[O:25])=[CH:18][CH:17]=1>>[N:12]1[CH:13]=[CH:14][C:9]([N:6]2[CH2:5][CH2:4][CH:3]([CH2:2][O:1][C:16]3[CH:21]=[CH:20][C:19]([CH2:22][CH2:23][C:24]([O:26][CH3:27])=[O:25])=[CH:18][CH:17]=3)[CH2:8][CH2:7]2)=[CH:10][CH:11]=1

参加物

3

反応物 2

HCID 79706Benzenepropanoic acid, 4-hydroxy-, methyl esterHCID 11310048(1-(Pyridin-4-YL)piperidin-4-YL)methanol

生成物 1

HCID 18918568Methyl 3-[4-[1-(4-pyridyl)piperidin-4-yl]methoxyphenyl]propionate収率 14%

実験手順

Following the method of Example 96, but starting from 4-(4-hydroxymethylpiperidin-1-yl)pyridine and methyl 3-(4-hydroxyphenyl)propionate, the title compound was prepared in 14% yield: m.p. 96.5°-98.5° C.; NMR (d6DMSO) δ 8.13(2H, d), 7.11(2H, d), 6.83(4H, m), 3.97(2H, dm), 3.81(2H, d), 3.56(3H, s), 2.87(2H, dr), 2.77(2H, t), 2.57(2H, t), 2.01(1H, m), 1.84(2H, m), 1.30(2H, m); m/e 355 (M+H)+ ; calculated for C21H26 N2O3.0.75H2O: C, 68.5; H, 7.2; N, 7.8. found: C, 68.5; H, 7.5; N, 7.6%.

出典と根拠

ORDレコード
ord-159bc692d5184caf89d71a09ee2cc756
出典データセット
uspto-grants-1998_03
特許番号
US05728701

関連ノート

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