Water → (4-(4-Methyl-3-pentenyl)-3-cyclohexenyl)acetonitrile

HRID 2227098ノート

反応式

HRID 2227098 の反応式
S([C:5]1[CH:11]=[CH:10][C:8]([CH3:9])=[CH:7][CH:6]=1)([O-])(=O)=O.[C-:12]#[N:13].[K+].O>CS(C)=O>[CH3:9][C:8]([CH3:10])=[CH:7][CH2:6][CH2:5][C:5]1[CH2:11][CH2:10][CH:8]([CH2:9][C:12]#[N:13])[CH2:7][CH:6]=1

参加物

5

反応物 3

HCID 962WaterHCID 9032Potassium CyanideHCID 85570p-Toluenesulfonate

生成物 1

HCID 18471789(4-(4-Methyl-3-pentenyl)-3-cyclohexenyl)acetonitrile

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒

反応条件

温度
100 °C

実験手順

To a solution of tosylate 1H (R=4-Methyl-3-pentenyl) (20 g) in dimethylsulfoxide (178 mL) is added potassium cyanide (19.4 g). The reaction mixture is heated to 100° C., and the reaction mixture is stirred at that temperature for three hours. The reaction mixture is cooled to room temperature, added to water (300 mL), and extracted with hexane. The combined organic layers are dried over magnesium sulfate and the solution is concentrated in vacuo.

後処理

  1. temperatureThe reaction mixture is cooled to room temperature
  2. extractionextracted with hexane
  3. dry with materialThe combined organic layers are dried over magnesium sulfate
  4. concentrationthe solution is concentrated in vacuo

出典と根拠

ORDレコード
ord-433844a784894642a04da8257ead6d84
出典データセット
uspto-grants-2002_07
特許番号
US06413448B1

反応ノート

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