Hydrochloric Acid → 4-Methoxyphenyl (4-(4-methyl-3-pentenyl)-3-cyclohexenyl)methyl ketone

HRID 2227101ノート

反応式

HRID 2227101 の反応式
[CH3:1][C:2]([CH3:16])=[CH:3][CH2:4][CH2:5][C:6]1[CH2:11][CH2:10][CH:9]([CH2:12][C:13](Cl)=[O:14])[CH2:8][CH:7]=1.[C:17]1([O:23][CH3:24])[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.Cl>ClCCl>[CH3:1][C:2]([CH3:16])=[CH:3][CH2:4][CH2:5][C:6]1[CH2:11][CH2:10][CH:9]([CH2:12][C:13]([C:20]2[CH:21]=[CH:22][C:17]([O:23][CH3:24])=[CH:18][CH:19]=2)=[O:14])[CH2:8][CH:7]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 7519AnisoleHCID 18471799(4-(4-Methyl-3-pentenyl)-3-cyclohexenyl)acetyl chloride

生成物 1

HCID 867582894-Methoxyphenyl (4-(4-methyl-3-pentenyl)-3-cyclohexenyl)methyl ketone

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

A solution of acid chloride 2C (R=4-Methyl-3-pentenyl) (10 g) in anhydrous dichloromethane (100 mL) is added dropwise to a mixture of ferric chloride (7.8 g) and anisole 2D (4.5 g) in dichloromethane (175 mL), cooled in an ice/ethanol bath. The resulting mixture is gradually warmed to room temperature and stirred overnight. The mixture is poured into 25% HCl (150 mL) and stirred for 30 minutes. The aqueous layer is extracted with dichloromethane, and the combined organic layers are sequentially washed with water, sodium bicarbonate, and water, then dried over magnesium sulfate. The solution is concentrated in vacuo.

後処理

  1. temperaturecooled in an ice/ethanol bath
  2. stirringstirred for 30 minutes
  3. extractionThe aqueous layer is extracted with dichloromethane
  4. washthe combined organic layers are sequentially washed with water, sodium bicarbonate, and water
  5. dry with materialdried over magnesium sulfate
  6. concentrationThe solution is concentrated in vacuo

出典と根拠

ORDレコード
ord-e3313ea46cd7402aa009ca69600977fe
出典データセット
uspto-grants-2002_07
特許番号
US06413448B1

反応ノート

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