Water → 4-(3-Bromopropyl)phenol

HRID 2227105ノート

反応式

HRID 2227105 の反応式
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10]O)=[CH:4][CH:3]=1.[Br:12]C(Br)(Br)Br.O>ClCCl>[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][Br:12])=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 962WaterHCID 11205Carbon tetrabromideHCID 824523-(4-Hydroxyphenyl)propanol

生成物 1

HCID 148170364-(3-Bromopropyl)phenol

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

To a solution of 3-(4-hydroxyphenyl)-1-propanol 3A (4.0 g) and tripohenylphosphine (7.96 g) in anhydrous dichloromethane (77 mL), cooled to 0° C., is added, dropwise, a solution of tetrabromomethane (9.59 g) in anhydrous dichloromethane (15.4 mL). The reaction mixture gradually warmed to room temperature and allowed to stir overnight. The solution is then poured into water and extracted with ethyl acetate. The combined organic layers are washed with brine and dried over magnesium sulfate. The solution is concentrated in vacuo.

後処理

  1. additionis added
  2. extractionextracted with ethyl acetate
  3. washThe combined organic layers are washed with brine
  4. dry with materialdried over magnesium sulfate
  5. concentrationThe solution is concentrated in vacuo

出典と根拠

ORDレコード
ord-ddc232abfd544438b4acbac4d5921aaa
出典データセット
uspto-grants-2002_07
特許番号
US06413448B1

反応ノート

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