Isobutylamine → N,N'-Di-iso-butyl DL-malamide

HRID 2227144

反応式

HRID 2227144 の反応式
[CH2:1]([NH2:5])[CH:2]([CH3:4])[CH3:3].[C:6]([O:16]CC)(=O)[CH:7]([CH2:9][C:10]([O:12]CC)=O)[OH:8]>>[CH2:1]([NH:5][C:6](=[O:16])[CH:7]([CH2:9][C:10]([NH:5][CH2:1][CH:2]([CH3:4])[CH3:3])=[O:12])[OH:8])[CH:2]([CH3:4])[CH3:3]

参加物

3

反応物 2

HCID 6558Isobutylamine2 回HCID 24197Diethyl malate2 回

生成物 1

HCID 13009116N,N'-Di-iso-butyl DL-malamide収率 29%

実験手順

N,N′-Di-iso-butyl DL-malamide was prepared by the reaction of iso-butylamine with diethyl DL-malate. To a round-bottomed flask were added diethyl DL-malate (5.229 g, 1 eq) and iso-butylamine (14.058 g, 7 eq). The clear light yellow solution was stirred for 24 hours at room temperature, after which point a white solid had precipitated from solution. The solid was filtered, washed with hexane (3×25 mL), and dried under vacuum (1.96 g, 29% yield). The product was >99% pure as determined by NMR analyses.

後処理

  1. customhad precipitated from solution
  2. filtrationThe solid was filtered
  3. washwashed with hexane (3×25 mL)
  4. customdried under vacuum (1.96 g, 29% yield)

出典と根拠

ORDレコード
ord-06a0a58c9b2c427fa329d30afdb1183d
出典データセット
uspto-grants-2002_07
特許番号
US06413914B1

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