5,6-Dichloro-2-ethynyl-1-(2,3-di-O-acetyl-5-deoxy-beta-D-ribofuranosyl) 1H-benzimidazole → 5,6-Dichloro-2-ethenyl-1-(5deoxy-beta-D-ribofuranosyl)-1H-benzimidazole
反応式
[Cl:1][C:2]1[C:26]([Cl:27])=[CH:25][C:5]2[N:6]([C@@H:11]3[O:23][C@H:22]([CH3:24])[C@@H:17]([O:18]C(=O)C)[C@H:12]3[O:13]C(=O)C)[C:7]([C:9]#[CH:10])=[N:8][C:4]=2[CH:3]=1>ClCCl>[Cl:1][C:2]1[C:26]([Cl:27])=[CH:25][C:5]2[N:6]([C@@H:11]3[O:23][C@H:22]([CH3:24])[C@@H:17]([OH:18])[C@H:12]3[OH:13])[C:7]([CH:9]=[CH2:10])=[N:8][C:4]=2[CH:3]=1参加物
3
実験手順
5,6-Dichloro-2-ethynyl-1-(2,3-di-O-acetyl-5-deoxy-beta-D-ribofuranosyl) 1H-benzimidazole (0.85 g, 0.20 mmol) was deprotected using general procedure III. Crude product was purified by silica gel chromatography using 1:10 methanol:dichloromethane to give the title compound as an off white solid (0.04 g, 0.12 mmol, 59%); MS (ES+): m/z (rel. intensity) 351 (15, M++Na);