Methylamine → HCID 178482440、化合物

HRID 2227527ノート

反応式

HRID 2227527 の反応式
[CH3:1][N:2](C)[C:3]1[O:4][CH:5]([CH:9]([C:11]2[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][C:18]=3[O:20][CH3:21])[NH:13][CH:12]=2)[CH3:10])[C:6](=[O:8])[N:7]=1.CN>>[CH3:21][O:20][C:18]1[CH:17]=[CH:16][CH:15]=[C:14]2[C:19]=1[C:11]([CH:9]([CH:5]1[O:4][C:3]([NH:2][CH3:1])=[N:7][C:6]1=[O:8])[CH3:10])=[CH:12][NH:13]2

参加物

3

反応物 2

HCID 6329Methylamine2 回HCID 18473977HCID 18473977、化合物

生成物 1

HCID 178482440HCID 178482440、化合物収率 67.1%

実験手順

2-dimethylamino-5-[1-(4-methoxyindol-3-yl)ethyl]-2-oxazolin-4-one (50 mg) was added to methylamine (5 ml). The mixture was refluxed for 5 hours and additional methylamine (5 ml) was added. The whole was further refluxed for 2.5 hours. The-methylamine was distilled off to give a residue, which was subjected to silica gel chromatography. Elution with hexane-acetone (1:1) provided the titled compound (32 mg).

後処理

  1. temperatureThe mixture was refluxed for 5 hours
  2. temperatureThe whole was further refluxed for 2.5 hours
  3. distillationThe-methylamine was distilled off
  4. customto give a residue, which
  5. washElution with hexane-acetone (1:1)

出典と根拠

ORDレコード
ord-c6066102b7c04af98708a751271ebd85
出典データセット
uspto-grants-2002_07
特許番号
US06414003B1

反応ノート

読み込み中…