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HRID 222754作成日：2026年10月27日

Methyl 3-hydroxy-4-methoxybenzoate → 1,1-Dimethylethyl 7-({2-(methyloxy)-5-[(methyloxy)carbonyl]phenyl}oxy)-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate

https://huagongshe.com/reaction/222754

反応式

関与物質

役割名称HCID仕込み量
反応物Methyl 3-hydroxy-4-methoxybenzoateHCID 4056967—
反応物(3-(tert-Butoxycarbonyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)boronic acidHCID 57440296—
生成物1,1-Dimethylethyl 7-({2-(methyloxy)-5-[(methyloxy)carbonyl]phenyl}oxy)-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylateHCID 57440301—

反応手順

The title compound was prepared from (3-{[(1,1-dimethylethyl)oxy]carbonyl}-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)boronic acid (E264, Step 2) and methyl-3-hydroxy-4-methoxybenzoate using the method of Example 264 Step 3; MS (ES+) m/e 328 [(M+H)—CO2tBu]+.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08207331B2
出典データセットuspto-grants-2012_06
ORD IDord-cce6cf95147746e3924fec0fadf0e1dd
出典メモuspto-grants-2012_06