Methyl 3-chloro-4-hydroxybenzoate → 1,1-Dimethylethyl 7-({2-chloro-4-[(methyloxy)carbonyl]phenyl}oxy)-1,2,4,5-tetrahydro-3h-3-benzazepine-3-carboxylate

HRID 222756

反応式

HRID 222756 の反応式
[CH3:1][O:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([OH:11])=[C:7]([Cl:12])[CH:6]=1)=[O:4].[CH3:13][C:14]([O:17][C:18]([N:20]1[CH2:26][CH2:25][C:24]2[CH:27]=[CH:28][C:29](B(O)O)=[CH:30][C:23]=2[CH2:22][CH2:21]1)=[O:19])([CH3:16])[CH3:15]>>[Cl:12][C:7]1[CH:6]=[C:5]([C:3]([O:2][CH3:1])=[O:4])[CH:10]=[CH:9][C:8]=1[O:11][C:28]1[CH:29]=[CH:30][C:23]2[CH2:22][CH2:21][N:20]([C:18]([O:17][C:14]([CH3:13])([CH3:15])[CH3:16])=[O:19])[CH2:26][CH2:25][C:24]=2[CH:27]=1

参加物

3

反応物 2

HCID 77580Methyl 3-chloro-4-hydroxybenzoateHCID 57440296(3-(tert-Butoxycarbonyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)boronic acid

生成物 1

HCID 685080111,1-Dimethylethyl 7-({2-chloro-4-[(methyloxy)carbonyl]phenyl}oxy)-1,2,4,5-tetrahydro-3h-3-benzazepine-3-carboxylate

実験手順

The title compound was prepared from methyl 3-chloro-4-hydroxy benzoate (320 mg, 1.72 mmol) and (3-{[(1,1-dimethylethyl)oxy]carbonyl}-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)boronic acid (E264, Step 2) using the method outlined in Example 264 Step 3 (211 mg, 29%); NMR (CDCl3) δ 1.49 (9H, s), 2.88 (4H, m), 3.56 (4H, m), 3.91 (3H, s), 6.78-6.89 (3H, m), 7.12 (H, m), 7.84 (H, m), 8.14 (H, s)

出典と根拠

ORDレコード
ord-e3a04f110eda4f0e9198dc580ead4b1c
出典データセット
uspto-grants-2012_06
特許番号
US08207331B2

関連ノート

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