3,5-Dichloroaniline → 2-(3,5-Dichlorophenylamino)nicotinic acid
反応式
Cl[C:2]1[N:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[Cl:11][C:12]1[CH:13]=[C:14]([CH:16]=[C:17]([Cl:19])[CH:18]=1)[NH2:15]>C(O)(=O)C>[Cl:11][C:12]1[CH:13]=[C:14]([NH:15][C:2]2[N:10]=[CH:9][CH:8]=[CH:7][C:3]=2[C:4]([OH:6])=[O:5])[CH:16]=[C:17]([Cl:19])[CH:18]=1参加物
4
実験手順
2-Chloronicotinic acid (10 g) was combined with 3,5-dichloroaniline (15 g) in 150 mL acetic acid and heated at reflux for 4 hr. Upon cooling, a white solid formed which was collected by filtration, washed with acetic acid, water, and dried to give 17.6 g of 2-(3,5-dichlorophenylamino)nicotinic acid.
後処理
- temperatureheated
- temperatureat reflux for 4 hr
- temperatureUpon cooling
- customa white solid formed which
- filtrationwas collected by filtration
- washwashed with acetic acid, water
- customdried
出典と根拠
- ORDレコード
- ord-49906059e42f44d1a88a703f71e97cdc
- 出典データセット
- uspto-grants-2002_07
- 特許番号
- US06414153B1
反応ノート
読み込み中…