関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 1-Fluoronaphthalene | HCID 9450 | — |
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 反応物 | 3-(Dimethylamino)-1-(2-thienyl)-1-propanol | HCID 11586409 | — |
| 反応物 | Potassium (2S,3S)-3-carboxy-2,3-dihydroxypropanoate | HCID 23687508 | — |
| 溶媒 | Dimethyl Sulfoxide | HCID 679 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | N,N-dimethyl-3-(naphthyloxy)-3-(2-thienyl)propylamine D-tartrate | HCID 86625060 | — |
反応手順
A mixture of N,N-dimethyl-3-hydroxy-3-(2-thienyl)propylamine (185 g, 1 mole), potassium hydroxide (112 g, 2 moles) and 1-fluoronaphthalene (146 g, 1 mole) in dimethylsulfoxide (1000 ml) is stirred at 110° C. for 2 hours. After cooling down to 20° C., the mixture is filtered, diluted with water (3 l), monopotassium D-tartrate (188 g, 1 mole) is added, and the mixture is stirred at 80° C. for 0.5 hour. After cooling down, the precipitated product is sucked off, washed with water and dried. Yield: 328 g (85%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08207356B2 |
|---|
| 出典データセット | uspto-grants-2012_06 |
|---|
| ORD ID | ord-51d09cc9bfbf42e897aa48296642bb8c |
|---|
| 出典メモ | uspto-grants-2012_06 |
|---|
