Acetic Acid → Ethyl 3-anilinobut-2-enoate

HRID 222788

反応式

HRID 222788 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:8]([O:14][CH2:15][CH3:16])(=[O:13])[CH2:9][C:10]([CH3:12])=O.C(O)(=O)C>>[NH:1]([C:10]([CH3:12])=[CH:9][C:8]([O:14][CH2:15][CH3:16])=[O:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 3

HCID 176Acetic AcidHCID 6115AnilineHCID 8868Ethyl Acetoacetate

生成物 1

HCID 94928Ethyl 3-anilinobut-2-enoate

実験手順

The title compound is commercially available. A mixture of aniline (9.785 mL, 107.4 mmol), ethyl acetoacetate (13.69 mL, 107.4 mmol), and acetic acid (0.6 mL, 10 mmol) was stirred at ambient temperature overnight. It was partitioned between heptane (50 mL) and sat. aq. NaHCO3 solution (50 mL). The organic layer was dried and evaporated to give the title compound of >90% purity that was used in the next steps without further purification.

後処理

  1. customIt was partitioned between heptane (50 mL) and sat. aq. NaHCO3 solution (50 mL)
  2. customThe organic layer was dried
  3. customevaporated

出典と根拠

ORDレコード
ord-1e6b975239ce4332973365ad3d45bb4c
出典データセット
uspto-grants-2012_06
特許番号
US08207347B2

関連ノート

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