Methanol → Methyl 3-methyl-5-phenylbenzoate

HRID 2228019ノート

反応式

HRID 2228019 の反応式
[CH3:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:10]=1)[C:5]([OH:7])=[O:6].[CH3:17]O>OS(O)(=O)=O>[CH3:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:10]=1)[C:5]([O:7][CH3:17])=[O:6]

参加物

4

反応物 2

HCID 887MethanolHCID 184745993-Methyl-5-phenylbenzoic acid

生成物 1

HCID 11379139Methyl 3-methyl-5-phenylbenzoate収率 94%

試薬・触媒・溶媒 1

HCID 1118Sulfuric Acid触媒

実験手順

A solution of 3-methyl-5-phenylbenzoic acid (3.5 g; 16.5 mmol) and concentrated H2SO4 (30 drops) in methanol (25 ml) was heated at reflux overnight. After evaporation to dryness, the residue was extracted with ether. The organic phase was evaporated and purified by flash chromatography eluting with petroleum ether/ethyl acetate (90/10) to give methyl 3-methyl-5-phenylbenzoate as an oil. Yield=94%.

後処理

  1. temperatureat reflux overnight
  2. customAfter evaporation to dryness
  3. extractionthe residue was extracted with ether
  4. customThe organic phase was evaporated
  5. custompurified by flash chromatography
  6. washeluting with petroleum ether/ethyl acetate (90/10)

出典と根拠

ORDレコード
ord-48ddedae0c894ffa8b2c2b9042f7762e
出典データセット
uspto-grants-2002_07
特許番号
US06414145B1

反応ノート

読み込み中…