2-Pyridinemethanol,a-(4-nitrophenyl)- → (4-Aminophenyl) (2-pyridyl)methanol
反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=2)[OH:11])=[CH:6][CH:5]=1)([O-])=O>C(O)C>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([CH:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=2)[OH:11])=[CH:6][CH:5]=1参加物
3
実験手順
In ethanol (50 ml) was dissolved (4-nitrophenyl)—(2-pyridyl)methanol (2.30 g), and to the mixture was added dried 10% palladium on carbon (0.12 g). Under hydrogen atmosphere, the mixture was stirred at room temperature under atmospheric pressure for 19 hours. The palladium was filtered off, and the filtrate was concentrated. The residue was recrystallized from ethyl acetate-hexane to give (4-aminophenyl) (2-pyridyl)methanol (1.90 g) as pale yellow crystals.
後処理
- additionto the mixture was added
- dry with materialdried 10% palladium on carbon (0.12 g)
- filtrationThe palladium was filtered off
- concentrationthe filtrate was concentrated
- customThe residue was recrystallized from ethyl acetate-hexane
出典と根拠
- ORDレコード
- ord-38fdd0d360d448d2b043a2f9b758a7fe
- 出典データセット
- uspto-grants-2002_07
- 特許番号
- US06413947B1
反応ノート
読み込み中…