Ethanol → Aminolevulinic acid phosphate

HRID 222816

反応式

HRID 222816 の反応式
Cl.[NH2:2][CH2:3][C:4](=[O:10])[CH2:5][CH2:6][C:7]([OH:9])=[O:8].[P:11](=[O:15])([OH:14])([OH:13])[OH:12].C(N(CC)CC)C.C(O)C>O>[P:11]([OH:15])([OH:14])([OH:13])=[O:12].[NH2:2][CH2:3][C:4](=[O:10])[CH2:5][CH2:6][C:7]([OH:9])=[O:8]

参加物

6

反応物 4

HCID 702EthanolHCID 1004Phosphoric AcidHCID 8471TriethylamineHCID 123608Aminolevulinic Acid Hydrochloride

生成物 1

HCID 24737828Aminolevulinic acid phosphate

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A 40 g (239 mmol) portion of δ-aminolevulinic acid hydrochloride and 18 ml (263 mmol) of 85% phosphoric acid were dissolved in 120 ml of purified water, and 25.4 g mmol) of triethylamine was added dropwise thereto while stirring on an ice bath. After completion of the dropwise addition and subsequent stirring at room temperature for 10 minutes, 1.6 L of ethanol was added thereto and stirred. The thus precipitated precipitate was recovered by suction filtration and dried at room temperature for 16 hours under a reduced pressure. A 51 g (224 mmol) portion of δ-aminolevulinic acid phosphate was obtained at a yield of 93 mol %.

後処理

  1. additionAfter completion of the dropwise addition
  2. stirringsubsequent stirring at room temperature for 10 minutes
  3. stirringstirred
  4. filtrationThe thus precipitated precipitate was recovered by suction filtration
  5. customdried at room temperature for 16 hours under a reduced pressure

出典と根拠

ORDレコード
ord-03aff9b54ec140d99b2fc56d12619989
出典データセット
uspto-grants-2012_06
特許番号
US08207376B2

関連ノート

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