化工社化工社 化学情報印刷レポート · 研究参考用
Formaldehyde → 5-Methoxy-2-methylindan-1-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Formaldehyde | HCID 712 | — |
| 反応物 | Hexane | HCID 8058 | — |
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 反応物 | 5-Methoxyindan-1-one | HCID 78787 | — |
| 触媒 | Pentacarbonyliron(0) | HCID 518773 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | 5-Methoxy-2-methylindan-1-one | HCID 12290490 | 44% |
反応手順
5-Methoxy indanone was treated with aqueous formaldehyde in the presence of iron pentacarbonyl and KOH in ethanol according to G. Cainelli et. al., Tetrahedron Letters 27, 2491 (1973). After chromatography (hexane:ethylacetate=7:3) over SiO2, a 44% yield of white crystals was obtained (m.p. 73-76° C.).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06416746B1 |
| 出典データセット | uspto-grants-2002_07 |
| ORD ID | ord-25fd0c8a62c34b399dc7840abb978e0e |
| 出典メモ | uspto-grants-2002_07 |