Ethyl cyanoacetate → 2-cyano-N-(prop-2-yn-1-yl)acetamide
反応式
[CH2:1]([NH2:4])[C:2]#[CH:3].CCO[C:8]([CH2:10][C:11]#[N:12])=[O:9]>>[C:11]([CH2:10][C:8]([NH:4][CH2:1][C:2]#[CH:3])=[O:9])#[N:12]参加物
3
実験手順
A mixture of 15.4 ml (240 mmol) of propargyl amine and 17.1 ml (160 mmol) of ethyl cyano acetate was heated for 7 hours to 40° C. in a reaction flask. The crystalline material formed was heated for another 17 hours to 70° C. Then, the cooled reddish product was dried at high vacuum to yield 18.4 g (94%) of a red powder, m.p. 100-103° C.
後処理
- temperaturewas heated for 7 hours to 40° C. in a reaction flask
- customThe crystalline material formed
- temperaturewas heated for another 17 hours to 70° C
- customThen, the cooled reddish product was dried at high vacuum
出典と根拠
- ORDレコード
- ord-eb07bdf180aa4aa5a3552ea2a0944690
- 出典データセット
- uspto-grants-2002_07
- 特許番号
- US06416746B1
反応ノート
読み込み中…