Hydroquinone → 1-(2-Methacryloyloxyethyl)indole

HRID 2228369ノート

反応式

HRID 2228369 の反応式
Cl[CH2:2][CH2:3][N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:6]=[CH:5]1.[C:13]([O-:18])(=[O:17])[C:14]([CH3:16])=[CH2:15].[K+].[I-].[K+].C1(C=CC(O)=CC=1)O>CN(C)C=O>[C:13]([O:18][CH2:2][CH2:3][N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:6]=[CH:5]1)(=[O:17])[C:14]([CH3:16])=[CH2:15]

参加物

6

反応物 4

HCID 785HydroquinoneHCID 4875Potassium IodideHCID 108992601-(2-chloroethyl)-1H-indoleHCID 23667354Potassium methacrylate

生成物 1

HCID 184697791-(2-Methacryloyloxyethyl)indole収率 78.9%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
100 °C

実験手順

Next, to a flask of 200 ml capacity fitted with a stirrer and cooling tube, there were introduced 15.4 g of 1-(2-chloroethyl)indole, 21.3 g of potassium methacrylate, 7.1 g of potassium iodide, 40 ml of N,N-dimethyl formamide and a small amount of hydroquinone. The mixture was heated to 100° C. and was stirred for 2.5 hours. After completion of the reaction, the insoluble material was removed by filtration, and concentration was performed under reduced pressure. This reaction mixture was then purified by column chromatography using silica gel, to obtain 15.5 g of 1-(2-methacryloyloxyethyl)indole.

後処理

  1. customNext, to a flask of 200 ml capacity fitted with a stirrer
  2. temperaturecooling tube
  3. customAfter completion of the reaction
  4. customthe insoluble material was removed by filtration, and concentration
  5. customThis reaction mixture was then purified by column chromatography

出典と根拠

ORDレコード
ord-635e3ff93a264caeb7583e02896f6427
出典データセット
uspto-grants-2002_07
特許番号
US06416939B1

反応ノート

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