2,3-Dihydro-1H-benzo[d]pyrrolo[1,2-a]imidazol-1-ol → 2,3-Dihydropyrrolo[1,2-a]benzimidazol-1-one
反応式
[OH:1][CH:2]1[N:9]2[C:5](=[N:6][C:7]3[CH:13]=[CH:12][CH:11]=[CH:10][C:8]=32)[CH2:4][CH2:3]1>C(Cl)Cl.C(OCC)(=O)C>[O:1]=[C:2]1[N:9]2[C:5](=[N:6][C:7]3[CH:13]=[CH:12][CH:11]=[CH:10][C:8]=32)[CH2:4][CH2:3]1参加物
4
実験手順
A solution of 2,3-dihydro-1-hydroxy-1H-pyrrolo-[1,2-a]benzimidazole (1.0 g, 5.75 mmol)) in methylene chloride was treated with mangenese dioxide (5 g, 58 mmol) at r.t. and stirred for 10 hour. The mixture was diluted with ethyl acetate and filtered through diatomaceous earth (Celite (trademark)). The filtrate was concentrated and purified to give the title compound. 1HNMR (CDCl3)δ 3.28 (t, 2H), 4.48 (t, 2H), 7.3-7.45 (m, 2H), 7.45-7.55 (m, 1H), 7.86-7.94 (m, 1H) ppm.
後処理
- filtrationfiltered through diatomaceous earth (Celite (trademark))
- concentrationThe filtrate was concentrated
- custompurified
出典と根拠
- ORDレコード
- ord-82cb599521bc42b6af01acc980576057
- 出典データセット
- uspto-grants-1995_06
- 特許番号
- US05428043
反応ノート
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