Cyclopropylamine → HCID 18466610、化合物
反応式
[Br:1][C:2]1[CH:3]=[C:4]([C:9]([NH:11][C:12]2[C:13]([Cl:20])=[N:14][C:15]([Cl:19])=[CH:16][C:17]=2[CH3:18])=[O:10])[C:5](Cl)=[N:6][CH:7]=1.[CH:21]1([NH2:24])[CH2:23][CH2:22]1>O>[Br:1][C:2]1[CH:3]=[C:4]([C:9]([NH:11][C:12]2[C:13]([Cl:20])=[N:14][C:15]([Cl:19])=[CH:16][C:17]=2[CH3:18])=[O:10])[C:5]([NH:24][CH:21]2[CH2:23][CH2:22]2)=[N:6][CH:7]=1参加物
4
反応条件
- 温度
- 0 °C
実験手順
A solution of 5-bromo-2-chloro-N-(2,6-dichloro-4-methyl-3-pyridinyl)-3-pyridinecarboxamide (3.00 g, 7.61 mmol) and cyclopropylamine (2.11 mL, 30.5 mmol) in xylenes was heated in a sealed tube at 120° C. for 24 h. The reaction was cooled to 0° C., diluted with water and extracted with EtOAc (2×). The combined organic extracts were dried (MgSO4), filtered and concentrated under reduced pressure. The resulting residue was purified by trituration (Et2O:hexane, 3:1) to give the title compound (2.35 g, 75% yield) as a pale yellow solid.