戻る
化工社化工社 化学情報印刷レポート · 研究参考用
HRID 222953作成日：2026年10月26日

4-(N-Boc-amino)piperidine → N-{3-[2-(4-amino-1-piperidinyl)-8-(2,6-difluorophenyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-4-yl]-4-methylphenyl}-6-chloro-3-pyridinecarboxamide

https://huagongshe.com/reaction/222953

反応式

関与物質

役割名称HCID仕込み量
反応物4-(N-Boc-amino)piperidineHCID 723833—
反応物6-chloro-N-{3-[8-(2,6-difluorophenyl)-2-(methylsulfonyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-4-yl]-4-methylphenyl}-3-pyridinecarboxamideHCID 59212686—
生成物N-{3-[2-(4-amino-1-piperidinyl)-8-(2,6-difluorophenyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-4-yl]-4-methylphenyl}-6-chloro-3-pyridinecarboxamideHCID 11947852—

反応手順

The title compound was prepared as described in Example 2 from 6-chloro-N-{3-[8-(2,6-difluorophenyl)-2-(methylsulfonyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-4-yl]-4-methylphenyl}-3-pyridinecarboxamide and 1,1-dimethylethyl 4-piperidinylcarbamate: LC-MS m/z 602 (M+H)+, 1.75 min (ret time).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08207176B2
出典データセットuspto-grants-2012_06
ORD IDord-c947980166374b55b743f41990313b23
出典メモuspto-grants-2012_06