Piperazine → 1-Phenyl-4-(1-piperazinyl)-1H-pyrazolo[3,4-d]pyrimidine

HRID 2230099

反応式

HRID 2230099 の反応式
[NH:1]1[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.Cl[C:8]1[N:13]=[CH:12][N:11]=[C:10]2[N:14]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[N:15]=[CH:16][C:9]=12>C(O)(C)C>[C:17]1([N:14]2[C:10]3=[N:11][CH:12]=[N:13][C:8]([N:1]4[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]4)=[C:9]3[CH:16]=[N:15]2)[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1

参加物

4

反応物 2

HCID 4837PiperazineHCID 2197524-Chloro-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine

生成物 1

HCID 8556141-Phenyl-4-(1-piperazinyl)-1H-pyrazolo[3,4-d]pyrimidine収率 88%

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

実験手順

To an isopropanol solution (10 mL) of piperazine (3.74 g, 43.4 mmol), 4-chloro-1-phenylpyrazolo[3,4-d]pyrimidine (100 g, 4.34 mmol) described in J. Org. Chem., 21: 1240-1256 (1956) was added, followed by heating under reflux for 6 hours. The reaction solution was concentrated, saturated brine was added thereto, the mixture was extracted with chloroform, the extract was washed with saturated brine and dried over anhydrous sodium sulfate, and then the solvent was evaporated to give the target compound (1.07 g, 3.82 mmol).

後処理

  1. addition, 21: 1240-1256 (1956) was added
  2. temperatureby heating
  3. temperatureunder reflux for 6 hours
  4. concentrationThe reaction solution was concentrated
  5. additionsaturated brine was added
  6. extractionthe mixture was extracted with chloroform
  7. washthe extract was washed with saturated brine
  8. dry with materialdried over anhydrous sodium sulfate
  9. customthe solvent was evaporated

出典と根拠

ORDレコード
ord-8a92fe3fcece4356bb472dc60d350135
出典データセット
uspto-grants-2002_07
特許番号
US06423716B1

関連ノート

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