Hydrochloric Acid → HCID 18180120、化合物
反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N+:9]([O-])=O)=[CH:5][C:4]=1[C:12]1[CH2:13][CH2:14][N:15]([CH3:18])[CH2:16][CH:17]=1.[ClH:19]>C(O)C>[ClH:19].[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([NH2:9])=[CH:5][C:4]=1[C:12]1[CH2:17][CH2:16][N:15]([CH3:18])[CH2:14][CH:13]=1参加物
4
実験手順
A solution of 4-(2-methoxy-5-nitrophenyl)-1-methyl-1,2,3,6-tetrahydropyridine (D37) (570 mg, 2 mmol), in ethanol (35 ml), was warmed to 60° C. and treated dropwise with a solution of stannous chloride (2 g) in cone. hydrochloric acid (4 ml). The mixture was heated for a further 2 h after addition, and allowed to cool. The precipitate was filtered off, and washed with ethanol to give the title compound (D39) as a pale yellow powder (580 mg, 99%). MH+=219.
後処理
- temperatureThe mixture was heated for a further 2 h
- additionafter addition
- temperatureto cool
- filtrationThe precipitate was filtered off
- washwashed with ethanol
出典と根拠
- ORDレコード
- ord-91bacd7149404a46ac2fb2c743d3eeb3
- 出典データセット
- uspto-grants-2002_07
- 特許番号
- US06423717B1
反応ノート
読み込み中…